In Anthony Trollope's novel "The Way We Live Now," the setting serves as a vivid backdrop that accentuates the societal contrasts and personal ambitions of its characters. At the heart of the narrative is Augustus Melmotte's extravagant residence in Grosvenor Square, Mayfair. This ostentatious home epitomizes the wealth and influence Melmotte wields, notwithstanding the dubious nature of his financial empire. While his grand abode stands in one of London's most prestigious areas, his business operations are more modestly situated in Abchurch Lane, a location steeped in the hustle and bustle of London's financial district. This dichotomy between his public persona and private dealings underscores the themes of deception and ambition that permeate the novel, as Melmotte's reach extends beyond London to international cities like New York, Hamburg, Vienna, and Paris.

Not far from the opulence of Grosvenor Square lies Welbeck Street, where Lady Carbury resides. This less-than-fashionable neighborhood reflects her struggle for literary recognition and financial stability. Lady Carbury, a determined hack writer, attempts to sway editors with favorable critiques of her subpar literary works. Her household includes her daughter, Hetta, and her prodigal son, Sir Felix Carbury, although Sir Felix frequently withdraws from the domestic sphere to seek entertainment at the Bear Garden Club. Situated off St. James Street, this exclusive club is central to the novel's plot, providing a stage for Sir Felix and his peers to indulge in hedonistic pursuits.

On Bruton Street stands the Longstaffe house, home to Adolphus "Dolly" Longstaffe's family. This fashionable address is ideal for engaging in London's social "season," yet financial constraints force the family to abandon their city residence and retreat to Caversham in Suffolk. For Georgiana Longstaffe, this enforced countryside existence is a profound embarrassment, while Dolly's property in Sussex, Pickering Park, becomes a pivotal element in Melmotte's eventual downfall.

Paul Montague, one of the novel's flawed heroes, is initially found residing on Sackville Street, north of Piccadilly. His journey through the narrative involves moving to Suffolk Street, signifying his shifting fortunes and evolving character. His involvement with Mrs. Hurtle, a femme fatale temporarily staying in Islington, provides further intrigue. This working-class area of London hosts a series of dramatic events, including Sir Felix's ill-conceived encounter with Ruby Ruggles and their shared visits to a music hall on City Road, painting a dynamic picture of London's diverse social landscape.