The narrator of the story is Violet Clay. After leaving her husband, Violet moves to New York City to pursue a career in painting. Throughout the story, Violet struggles to come to terms with the loss of her parents and her uncle's suicide.

Lewis Lanier is Violet's husband.

Liza Lee was Violet's mother, who committed suicide due to postpartum depression and the loss of her husband.

Ambrose was Violet's uncle. His alcoholism and his failures as a novelist led to his suicide.

Samantha De Vere is Ambrose's neighbor who helps Violet grieve.

Georgette is Violet's grandmother and a former concert pianist. She gave up her career to have a family.

Violet Pardee is Georgette's best friend, also known as "The Big V."

Ivor and Jake are two lovers Violet takes after her divorce. Ivor is an art instructor, and Jake is a musician.

Milo is Violet's best friend.