Both Madame de Thoux and Cassy share family ties with the Harrises, so they travel to Canada together, seeking their long-lost family members. They find the Harris family in Montreal, where Eliza and George have been free for five years. Their son Harry is older now, and little Eliza, their daughter, is the newest member of the family. 

When Cassy sees her daughter and granddaughter, she undergoes a spiritual change, and Eliza convinces her that Christianity is a good way to live. Madame de Thoux offers to give the family some of her money, and George requests she help him pay to go to school. Emmeline goes with the group as they sail across the ocean to France. Emmeline meets a crew member of the ship and falls in love with him. In the end, they get married. After living in France for four years, the Harrises move back to Canada.

George talks about his plans for the future in a letter to a friend. He says that he feels bad for Africans who were sold into slavery and that he wants to go to Africa because that is where he comes from. He and Eliza, along with the rest of the family, eventually go there to become missionaries.

The reader also finds out that Miss Ophelia freed Topsy and took her back to Vermont. Topsy went to school and got baptized. She then followed the Harris family to Africa to become a missionary.

Master George goes back to Kentucky and tells Mrs. Shelby and Aunt Chloe the sad news about Tom. A few months later, Master George calls all of the servants together and tells them that he has written papers to set them all free. Those who stay at the plantation get paid for the work they do, so they never have to worry about being slaves again if something happens to Master George. Master George tells his workers that he promised on Uncle Tom's grave that he would never own any more slaves and that they should be thankful to Tom. He does this to honor Tom’s kindness and ensure his memory does not die.