Calhoun shared his statements on slavery eleven years prior to the Civil War beginning. His greatest and clearest concern for the United States was the division occurring in the nation over the subject of legalized slavery in the South. Calhoun stated that although the subject had been discussed and debated for many years prior to 1850, the nation was becoming more and more divided, not unified.

As many in the South justified slavery as an economic necessity for their way of life and as a moral social establishment, Calhoun sought to explain the reasons the northern and southern states were clashing over the issue. He stated that when the Constitution was written, the states were roughly balanced in terms of population. As well, there was an equal number of Northern and Southern states. However, he asserted that in 1850, this balance was no more, and the North had the advantage in the legislative branch. Therefore, Southern states feared that they would lose to Northern power.

Additionally, he stated that the Northern states had made many "aggressions" "on the rights of the South," as many Southerners viewed slavery as a right of Southern states. Calhoun defended the rights of Southern states to protect themselves. Calhoun also supported Southern complaints that many historical land agreements previously passed were more advantageous to the North, and the South did not receive as much land. He cited the Land Ordinance of 1787, the Louisiana Purchase, and the Mexican Cession.

Calhoun provided clear arguments for states' rights and sovereignty against unjust federal acts of power. He claimed that there are diverse interests and positions taken in Northern and Southern states and that citizens in each region should be able to defend their positions. In regard to slavery, Calhoun stated that "this hostile feeling on the part of the North toward the social organization of the South" has endured for a long time. He argued that if the North continued to have dominance in federal affairs, the Southern way of life would be forcibly altered.

Calhoun addressed the various reasons why the bonds of the Union were beginning to break; he even cited religious reasons; he explained changes in Christian denominations in various parts of the country. He posed the question of how federal officials can save the Union and keep the nation from fracturing. His solution lay in granting Southern states more freedom and representation in the government. Calhoun even addressed the dangerous notion of the secession of the South. In his argument for more representation for the South, Calhoun also included great discussion about present and future territories (like California) entering the Union. He also addressed how the South could gain more land.

Calhoun provided great challenges for Northern statesmen to consider if they wanted to preserve a unified America.