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Simon vs. the Homo Sapiens Agenda is a 2015 young adult novel by Becky Albertalli. It follows the protagonist, Simon, who strikes up an amorous email chain with a classmate who goes by the pseudonym "Blue." Simon's classmate Martin stumbles upon the emails and leverages Simon's fear of being outed as gay to enlist his help in courting Abby Suso, Simon's friend whom Martin has a crush on.

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Simon hides the imminent outing to Blue, and he ends up juggling several conflicting impulses. One is the need to accommodate Martin, who gets increasingly jealous of Simon's effortless closeness to Abby. Another is a love triangle that has formed between Abby and his friends Nick and Leah. Amid all of this, Simon tries to figure out the real identity of Blue. He uses clues from the emails to hypothesize that it is Cal, a member of the school musical. He also struggles with conflicting attractions to two jocks named Garrett and Bram.

Martin vindictively decides to post a public message to the school's online news board under Simon's name, coming out of the closet on his behalf. This forces Simon to come out to his family prematurely and endure bullying at school. When Blue distances himself from Simon, Simon lashes out at Martin, rejecting his apology.

Simon repeatedly tries to reconnect with Blue until Blue eventually sends him a t-shirt of his favorite band. After being grounded for getting drunk during an outing in the city, Simon offers to meet Blue at the carnival party after the musical. He is disappointed when Blue doesn't show up at their meeting spot, but he waits until the end of the carnival. Blue reveals at the last minute that he is Bram. At the end of the novel, Simon and Bram spend time together, and look forward to taking their relationship wherever it may go.

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