His heart is lifted up to God at all times, and in all places.

With this statement, Wesley emphasizes the importance of connecting with God. One of the most famous images in Christianity, specifically Roman Catholicism, is the Sacred Heart of Jesus Christ and his mother, the Virgin Mary. In the Methodist and other Protestant sects, this symbolic union of the hearts can be applied to the relationship between mortals and the supernatural creator known as God.

He walks with God continually; having the loving eye of his soul fixed on him, and everywhere seeing Him that is invisible.

This is another example of Wesley emphasizing the importance of people's connection with God. Wesley believes that the soul is intertwined with God. This theme of symbiosis is prevalent throughout the text, and it can be argued that this is the main thesis.

Indeed, how God may work, we cannot tell.

This excerpt shows the logic of Christian scholars and preachers. Essentially, it prevents arguments against the word of God, for the ways of God, as well as His teachings, are a mystery. This means that God has His own logic and reasoning that cannot be fathomed by humans.