Sefelt is one of the patients who does not take his medicine in One Flew Over the Cuckoo's Nest. As a result, in Chapter 19, he suffers an epileptic fit while waiting in the lunch line. His tray flies into the air, and food rains down on him. An orderly has to put a stick in Sefelt's mouth as he is having a fit, and the wooden stick splinters from Sefelt's bite.
Nurse Ratched says that Sefelt has not been taking his Dilantin, which is an anti-convulsant, and has instead been holding it in his mouth and then giving it to Bruce Fredrickson, another patient with epilepsy who sleeps next to Sefelt. Fredrickson wants to take a double dose, while Sefelt does not want to take any Dilantin. Sefelt cares about his looks, and he thinks the medicine makes his hair fall out and his gums rot.
In addition, patients such as Mr. Taber, who refuses to take his medicine orally, is forced down onto a mattress and is given his medicine in a shot with a long needle.