Oliver Wendell Holmes was born on August 29, 1809, in Cambridge, Massachusetts, a town that had already become established as a major American cultural center by virtue of Harvard College and nearby Boston—“the hub of the solar system,” as Holmes would note only half jokingly in Essay VI of The Autocrat of the Breakfast-Table. Holmes’s father, Abiel Holmes, was a Congregational minister in Cambridge who had already established his reputation as a writer with The Annals of America (1805, 1829), generally regarded as the first attempt at an exhaustive compilation of American historical data beginning with 1492. Holmes’s mother, Sarah Wendell, was a descendant of the noted Puritan poet Anne Bradstreet; indeed, like Bradstreet, she was unusually liberal on religious issues, and her son—far from following in the devout footsteps of his clergyman father—had little patience with religious orthodoxy.
From an early age, Holmes was fascinated by natural science, and he is reported to have devoted the playtime of his childhood to analyzing the snails and insects that he found in the family’s garden, but his decision to pursue a career in medicine—which, contrary to popular belief, probably was not because of his passion for driving horse carriages at illegal speeds through the streets of Boston—would not come until much later. After a year (1824-1825) at a Calvinist preparatory school, Phillips Academy at Andover, Holmes entered nearby Harvard College and graduated in 1829 as class poet.
Still undecided as to how best to use his unusual talents, he entered Dane Law School in Cambridge and remained there for one year (1829-1830); he then enrolled at Boston’s Tremont Medical School, which he attended until 1833. This training was followed by two years of intensive study in Paris, a city that in the 1830’s was noted for its superb facilities for medical research and that attracted the brightest medical students in the United States. In 1836, Holmes received his M.D. degree from Harvard and immediately commenced his extraordinary career as a physician, research scientist, and teacher.
In 1836 and 1837, Holmes won three Boylston Prizes for his essays titled “The Nature and Treatment of Neuralgia,” “Facts and Traditions Respecting the Existence of Indigenous Intermittent Fever in New England,” and “The Utility and Importance of Direct Exploration in Medical Practice.” His 1843 essay “The Contagiousness of Puerperal Fever,” generated widespread controversy in its day, and it was not until 1861 that the Hungarian obstetrician Ignaz Philipp Semmelweis confirmed Holmes’s theory that the deadly “childbed fever” was spread by contagion—that, in fact, it was often transmitted by the midwives and physicians who attended births. Holmes also was a...
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