Steinbeck's brief, ironic idyll of the American dream gone wrong offers substantial food for thought. The majestic West and the dreams of ordinary people evoke strong empathy for the novel's main characters. It is unsurprising that readers might have strong reactions to Steinbeck's grim depiction of their downfall. Readers might feel conflicted between their sympathy for Lennie and the authorities' need to hold him accountable for his crime. They may also have mixed feelings about George's actions in protecting his friend, knowing that Lennie will eventually need assistance that George cannot provide.

1. Like many authors, Steinbeck selects a phrase from another literary work for his title, specifically from the Scottish poet Robert Burns's "To a Mouse." How does this allusion enhance the depth of the author's portrayal of his Western drifters?

2. Throughout Of Mice and Men, Steinbeck integrates animal imagery into his character descriptions. Why does he do this? What does this technique reveal about character and theme?

3. Steinbeck depicts Curley's wife as a vixen and a temptress, the archetypal femme fatale. Is this portrayal believable? Does the author rely too heavily on readers' acceptance of her superficial motivations and overt sexuality?

4. Some critics have argued that through George and Lennie's friendship, Steinbeck presents an acceptable portrayal of love between two men. Do you agree? Is their relationship a healthy one?

5. One of the novel's most poignant scenes is the killing of Candy's dog by Carlson. Why does Steinbeck include this scene in the story?

6. Although George wants to keep his plans about owning a ranch secret, both Crooks and Candy learn of the scheme and wish to join. Why? What does this reveal about the significance of George's plan?

7. Compare the characters Slim and Curley. In what ways are they alike? How does Steinbeck use them to represent opposing forces in human nature?

8. In a concise novel like this, economy of detail is crucial: the author must make effective use of everything included in the story. Select several passages where Steinbeck demonstrates his ability to convey a lot about his characters or foreshadow upcoming events. Discuss how these details enrich your understanding of the story.

9. What role does Crooks play in the novel? What is the significance of his being black?

10. The first four paragraphs of chapter 6 describe a heron fishing in a pool in the Salinas River. Why do you think Steinbeck includes this scene? Why does he place it at the start of the final chapter?