Of Mice and Men recounts the story of two itinerant ranch hands who, despite their apparent differences, are dependent on each other. Lennie Small, by far the better worker of the two, suffers not only from limited intelligence but also from an overwhelming desire to caress soft objects. These traits, combined with his uncontrollable strength, set the stage for disaster.

The fact that a disaster has not already occurred is largely the result of the vigilance of Lennie’s traveling companion, George Milton. Being aware of Lennie’s limitations, George does his best to keep Lennie focused on their mutual dream of owning their own spread, raising rabbits, and being in charge of their own lives. He also ushers Lennie out of town whenever the locals misinterpret his friend’s actions.

When the reader first encounters Lennie and George, they are setting up camp in an idyllic grove near the Gabilan mountains. It is lush and green and inhabited by all varieties of wild creatures. It represents, as the ensuing dialogue makes clear, a safe haven—a place where both humans and beasts can retreat should danger threaten. This setting provides author John Steinbeck with a context against which to portray the ranch to which George and Lennie travel the next day. The ranch, as he describes it, is a world without love and in which friendship is viewed as remarkable.

Steinbeck frames the desolation of ranch life by having George and Lennie comment on how different their lives are and having the other ranch hands comment on how unusual it is for two men to travel together. The hired hands have no personal stake in the ranch’s operation and, for the most part, no stake in one another’s well-being. Although they bunk together and play an occasional game of cards or horseshoes, each is wary of his peers. It is for this reason that Lennie and George’s friendship is questioned by everyone and why their dream of owning their own place is so infectious, especially to men such as Crooks and Candy, both of whom long to escape this loveless, isolated existence. Complementing this theme are the description of Candy and his dog and Crooks’s analysis of what it means to have a friend. Even Curley’s wife is used to reinforce the message. She is a woman who, despite her own dreams of grandeur, finds herself living on a ranch where she is perceived as a threat and an enemy by all the hired hands.

To underscore the situation, Steinbeck adopts restricted third-person narration and employs a tone that can best be described as uninvolved. His technique is an outgrowth of his desire to fuse dramatic and novelistic techniques into a new literary format, which he called the “play-novelette.” Accordingly, he relies on setting and dialogue to convey his message. For this reason, he begins each chapter with a compendium of details that allows readers to envision the scenes much as they might were they watching a staged presentation. Once he has outlined the surroundings, however, he steps away and relies on dialogue to carry the main thread of the story.

Significantly, Steinbeck begins and ends the novel at the campsite. This circular development reinforces the sense of inevitability that informs the entire novel. Just as Lennie is destined to get into trouble and be forced to return to the campsite so, too, will George be forced to abandon the dream of owning his own farm. Instead, he will be reduced to the status of a lonely drifter, seeking earthly pleasures to alleviate the moral isolation and helplessness that Steinbeck suggests is part of the human condition.