Perhaps the biggest difficulty for Odysseus to face as predicted by Tiresias is the wrath of Poseidon, who is furious with Odysseus for blinding his son, the Cyclops named Polyphemus. Tiresias states that Poseidon intends to follow Odysseus, causing difficulties and problems as revenge for his son. However, Tiresias provides a solution for that problem: Odysseus must sail through a narrow strait which is where Scylla and Charybdis reside, both of whom are fearsome monsters who would kill most or all of them.
Tiresias also warns Odysseus not to touch the cattle of Helios, otherwise he and his crew will be destroyed.
Finally, Tiresias tells Odysseus of what he will find when he finally reaches Ithaca: the suitors who have been causing trouble in his home. However, Odysseus will take care of the suitors by killing them.
All of this takes place in Bk. 11, lines 111-133.