1. Why was the rats' time at the Boniface Estate a crucial transition between their experience at NIMH and their life at the Fitzgibbon farm?

2. In what ways does the rats' developed society on the Fitzgibbon farm resemble their earlier years at the marketplace?

3. Jeremy mentions that the rats on Mr. Fitzgibbon's farm kept to themselves. What are some reasons for this behavior? What did they learn after escaping NIMH that led them to avoid others?

4. Why did Jonathan Frisby never tell his wife about NIMH? Was his choice justified?

5. How is "bravery" defined? Which characters exhibit this trait?

6. Is there a difference in the portrayal of human and animal characters' personalities?

7. How is Thorn Valley depicted? Why is it significant that this location was chosen for the Plan?

8. Do you believe the rats' plan for a society in Thorn Valley will be successful? What challenges do you anticipate? How might they address these issues?

9. How is science utilized in the novel? Compare its application by Dr. Schultz, Mr. Ages, and the rats.

10. The fate of many characters remains unknown. For a long time, Mrs. Frisby was unaware of how her husband died. Two unresolved questions at the novel's end involve Jenner and Justin. What are other unanswered questions? Why does O'Brien leave them unresolved?

11. Some characters, settings, and actions in the novel have both harmful and beneficial aspects. For instance, plowing can harm animals, but it also provides food for them. What are other examples of this duality? How does this reflect real life? Is it a confusing or accurate depiction of life?