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What does Macbeth's reaction to Lady Macbeth's death in act 5 reveal about their relationship and his mindset?

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Macbeth's reaction to Lady Macbeth's death in Act 5 reveals his deep depression and sense of life's futility. His indifference to her death and the "tomorrow and tomorrow" soliloquy illustrate his weary, nihilistic perspective. This reaction shows how their relationship has deteriorated and highlights Macbeth's transformation into a callous, self-pitying tyrant, consumed by regret and disillusionment.

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When Macbeth hears news of his wife's death he sounds indifferent, saying:
She should have died hereafter [at some point anyway].
He then launches into his famous "tomorrow and tomorrow" soliloquy about being weary of life. This shows that Macbeth is depressed, miserable, and consumed with self pity. He has...

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changed drastically from the hopeful man with a conscience that he was inAct I.
He was a man who believed that becoming king would make all his dreams come true. Instead, becoming king has made his life a living nightmare. It has led him down a very bloody path, killed the humanity inside of him, and caused him to realize he is not fit for the crown. As Angus says of Macbeth at the beginning of Act V, scene 2
Now does he feel his title
Hang loose about him, like a giant’s robe
Upon a dwarfish thief
It must feel terrible to get the position you have long coveted and realize you are incompetent in it. Macbeth, his dreams dashed, can only hope, at this point, that against all odds, he can stave off the armies facing him, and after that, go back to a miserable existence. He says he has nothing to look forward to in old age: no love, no honor, no obedience, no friends. In his miserable state, he feels sorry for himself, he can't feel anything about his wife, he is deeply depressed, and he looks forward only to "curses:"
[I] have lived long enough. My way of life
Is fall'n into the sere, the yellow leaf,
And that which should accompany old age,
As honor, love, obedience, troops of friends,
I must not look to have, but, in their stead,
Curses
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Macbeth is despondent when he learns of her death, and his sorrow contains some of the most quoted lines in all of Western literature:

"She should have died hereafter;
There would have been a time for such a word.
Tomorrow, and tomorrow, and tomorrow,
Creeps in this petty pace from day to day,
To the last syllable of recorded time;
And all our yesterdays have lighted fools
The way to dusty death. Out, out, brief candle!
Life's but a walking shadow, a poor player
That struts and frets his hour upon the stage
And then is heard no more. It is a tale
Told by an idiot, full of sound and fury
Signifying nothing" (5.5.17–27).

After news of the queen's death, Macbeth himself resolves to die, rushing into battle, crying out, "Blow, wind! come, wrack! / At least we'll die with harness on our back! (5.5.50–51).

In 5.8, Malcolm reports that Lady Macbeth died "by self and violent hands," and that all attempts to prevent the witches' prophecies from coming to pass have failed. The tragedy of Macbeth is complete.

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