There are several strange physical symptoms of Lady Macbeth’s troubled conscience that are witnessed by the doctor on Act V Scene i.

Firstly, he sees her sleepwalking with her eyes open-

A great perturbation in nature, to receive at once the
benefit of sleep and do the effects of watching!

The next action is that she is moving her hands as if washing them-

 Look how she rubs her
hands.

 The doctor is also concerned that she is talking as she moves-

Hark, she speaks!

 These physical symptoms together demonstrate a profound mental disturbance. As Lady Macbeth is clearly talking about a crime involving a death and blood, it is obvious that she has more than a medical complaint to deal with. The doctor decides that she -

More needs she the divine than the physician.