- Both Victor Frankenstein and the Creature are victims of isolation. At first, Victor's isolation is self-imposed, a result of his intense scientific study. Later, the Creature's rage at being made an outcast leads him to isolate Victor by means of violence and intimidation.
- Nature and its subversion are important themes in Frankenstein. Victor breaks the laws of nature when he raises the Creature from the dead. His arrogance results in chaos and destruction.
- Nothing is quite what it seems in Frankenstein. Though the Creature may look monstrous, he is a thoughtful, sympathetic creature driven to violence by circumstance rather than nature.