Victor's first emotional reaction is one of shock. When the creature comes to life, he is very different from what his creator had envisioned. As Victor states below, he had tried to build a "beautiful" being. He says,
How can I describe my emotions at this catastrophe, or how delineate the wretch whom with such infinite pains and care I had endeavoured to form? His limbs were in proportion, and I had selected his features as beautiful. Beautiful! Great God!
He goes on to explain that he felt emotions of horror mingled with "bitter disappointment." He finds the creature unbearably physically repulsive, so much so that the his entire world turns upside down in an instant:
the beauty of the dream [of creating life] vanished, and breathless horror and disgust filled my heart. Unable to endure the aspect of the being I had created, I rushed out of the...
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room and continued a long time traversing my bedchamber, unable to compose my mind to sleep.
After Victor sees the creature walking, he is even more horrified:
A mummy again endued with animation could not be so hideous as that wretch. I had gazed on him while unfinished; he was ugly then, but when those muscles and joints were rendered capable of motion, it became a thing such as even Dante could not have conceived.
Victor's physical reactions to the creature are extreme. They include sleeplessness and nightmares. He alternates between a very rapid pulse and near fainting. Both his physical and his emotional desire is to keep the creature out of sight.
Victor clearly became so fixated on creating life that he never stopped to think through the implications of what he was doing, and thus he was wholly unprepared for the results.
Victor has pumped himself up so much with anticipation to see the animated creature that probably no one/nothing would have satisfied him. Nevertheless, he grossly overreacts when he beholds his live creation, now capable of expression, intent, and emotion. The pieces he thought looked good while it was still dead either seem not properly animated or too much so. The eyes bothered him by looking at him as well.
His yellow skin scarcely covered the work of muscles and arteries beneath; his hair was of a lustrous black, and flowing; his teeth of a pearly whiteness; but these luxuriances only formed a more horrid contrast with his watery eyes, that seemed almost of the same colour as the dun-white sockets in which they were set.
Even more, Victor's interpretations of the creature's actions seem indicative of his own mental state. He tries to avoid it behind the curtain but its curiosity seeks him out. Even a smile is suspicious. Its outstretched arm seems so threatening--"seemingly to detain me"--that Victor doesn't just move safely out of reach but runs off in horror mixed with fear.
In stark contrast to Dr. Frankenstein's expectations upon succeeding at a task at which he had labored for two years, in effect, the anticipation of exhilaration, he was instead horrified by the sight before him. The hideousness of his creation was immediately too much for him to bear, and he fled the room. His next encounter with his creation was when, as he lay in bed, the creature approached him with curiosity. Again, Frankenstein fled both out of fear and repulsion.
The enormity of the creature and its horrific appearance, aptly described in Volume I, Chapter 4, caused Dr. Frankenstein to instantly regret his labors to reanimate human tissue.