Why does Victor in Frankenstein consider himself as the "true murderer" and his hands "thrice accursed"?

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Interesting question! In the book Frankenstein by Mary Shelley, Victor feels remorse and guilt for making the creature. As the book progresses, Victor places the creature’s inhumane actions upon his own shoulders. This is especially seen through Justine’s conviction.

During Justine’s trial for the murder of William, Victor feels such guilt that he wishes to confess to the murder. However, Victor realizes that no one would believe him about making the creature. Eventually Justine confesses and is hanged (despite her innocence), causing Victor to feel further regret. This represents his “thrice-accursed” hands. The first was creating the monster, the second was the creature’s murder of William, and the third was Justine’s death.

Despite the guilt that Victor feels from his “thrice-accursed” hands, his own actions (and lack of action) caused the creation of the monster and the death of William and Justine. For example, Victor's own actions made the creature, which led to William and Justine’s deaths. Lastly, his inaction also incited negative repercussions. For example, Victor failed to even address the very creature’s existence, until it was too late.

As a result, Victor experienced much pain and agony. However, his own choices led to the suffering that ensued.

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