The House of Holiness is described in book 1, canto 10, of The Faerie Queene and is a complete contrast to the Cave of Despair in the previous canto, as well as a strong symbolic opposite to the House of Pride earlier in the poem. It is the place where all the Christian virtues may be found, and it is here that the Redcrosse Knight, who has just come close to suicide in canto 9, is able to recover his strength.

The House of Holiness has a hospital, but it is his spiritual strength rather than physical vigor that the Redcrosse Knight so desperately needs to regain. He is revived by the care of Caelia, who has three daughters: Fidelia, Speranza, and Charissa. The names of these ladies reveal the religious allegory of the House of Holiness. Caelia means "Heavenly Spirit," and her daughters represent the three virtues of Faith, Hope, and Charity.

It is this spirit and these virtues that restore the Redcrosse Knight to health and allow him to fulfill his symbolic function at the center of the poem, a function he came close to losing when driven to despair in canto 9.