God and religion are central to both authors, reflecting the world both men occupied.

Dante is not particularly reverent toward the Catholic Church in his The Divine Comedy. Many corrupt clergyman end up in Dante's hell, as do most of the recent popes, showing that Dante was willing to point a finger at the evils in the Church.

Boccaccio's Decameron is also not reverent towards the Catholic church. It is a portrait of worldly and corrupt clergy with the same passions the rest of humanity has, despite their vows of poverty, chastity, and obedience. It could be said that Boccaccio shows the actions in this life that lead the clergy to hell in the next life.

But while both authors illustrate the corruption in the church, Dante's focus in The Divine Comedy is on the otherworldly and the spiritual. The narrator is feeling lost in the middle of life—he is 35—and Virgil is guiding him on his journey to hell, purgatory, and heaven to try to bring him back to into a closer relationship with God. The connection to the divine and the reclamation of lost faith is central to this work.

Central to The Decameron, however, is life in this world. Boccaccio might show the vices of the clergy, but he has no interest in using this as a moral springboard to the religious reclamation of any particular character. This may be because Boccaccio adapts stories from non-Christian traditions, using tales from Persia, India, and other parts of the Arab world.

I wouldn't call The Decameron anti-Dantean, as it condemns the church as much as The Divine Comedy, but I would say its focus is on enjoying the world in the context of a deadly plague that could take anybody at any time, versus Dante's concern with the spiritual world and the life of the soul.