One of the main themes in Black No More by George S. Schuyler is racism. The author criticizes white people who use racism to make money. He also criticizes black leaders for trying to please their white friends at the expense of their African American constituents.

Another theme that can be found in the book is science and technology. In the novel, Dr. Junius Crookman, a black doctor, develops a method that can change a black person into a white person. By narrating the story, the author wonders what would happen if this technology were available. The invention by Crookman is the basis of the entire story.

Deception is another theme in the story. Max Disher uses Crookman's method to deceive people. For instance, he lies to a white woman about his race and eventually marries her. Furthermore, he plots to become the head of Knights of Nordica so that he can organize sham fundraisers and enrich himself. In addition, Max changes his name to Matthew Fisher.