[Me and You and a Dog Named Blue] has many ambiguities and dimensions; the reader never fully understands CoCo's puzzling character or motivation (nor does Maggie), there is no definite resolution of the problem of Maggie's future, and some characters appear without apparent reason. But it is this very uncertainty that gives the book the feeling of a piece of real, ongoing life.
Ann A. Flowers, "Stories for Intermediate Readers: 'Me and You and a Dog Named Blue'," in The Horn Book Magazine (copyright; © 1979 by The Horn Book, Inc., Boston), Vol. LV, No. 3, June, 1979, p. 300.