Feelings of unexplained sadness and loss of interest in once-loved activities are typically symptoms indicative of depression.

Cognitive therapy for depression would involve encouraging Wilma to think healthy, happy thoughts, even if she has to read them out by rote at first. According to cognitive therapy, a thought leads to a mood. Exchanging negative thoughts for positive ones will therefore help Wilma to feel better.

According to behaviorists, depression comes about as a lack of positive reinforcement. Therapy involves developing "short, medium, and long-term life goals" in order to increase positive awareness. A behavioral psychologist would encourage Wilma to plan more activities that she enjoys doing and have her track the effect that these activities have on her emotions. Wilma's behavioral therapist would examine the behaviors that contribute to her depression and then target them specifically.

Pharmacological interventions would involve prescribing antidepressant medications. Every patient in different, and it may take a few different attempts to find the right medication for Wilma. Wilma would need to understand that these medicines take time to work, and they may come with side effects that she will need to discuss with her doctor. Wilma may even feel worse before she begins to feel better once she starts her pharmacological intervention.