While planning for, leaving for, and while in England (as described in chapters 18 and 19 of Mary Shelley's Frankenstein), Victor is extremely unhappy. Victor's trip to England is for one reason, to create another creature (with the hopes that it will not be like his previous one (murderous) and that it will insure the pair's self-exile from the lands inhabited by man).
In chapter eighteen, Victor states his unhappiness regarding his impending trip to England.
I had an insurmountable aversion to the idea of engaging myself in my loathsome task in my father's house, while in habits of familiar intercourse with those I loved.
That being said (Victor's task is one he is averted to), Victor understands why he must be successful.
For myself, there was one reward I promised myself from my detested toils—one consolation for my unparalleled sufferings; it was the prospect of that day when, enfranchised from my miserable slavery, I might claim Elizabeth, and forget the past in my union with her.
Upon arriving in England, a remote island in the Orkneys, Victor's unhappiness is apparent.
As I proceeded in my labour, it became every day more horrible and irksome to me. Sometimes I could not prevail on myself to enter my laboratory for several days.
Essentially, Victor's trip to England was one which brought him extreme sadness. The trip, meant to lessen his worries about any further destruction by the creature, only brought him more sadness. His upcoming marriage to Elizabeth, his creation of the initial creature, and the fact his creature caused the deaths (both directly and indirectly) of William, Justine, and his father forced Victor to make a deal with the devil.