In Of Mice and Men, why is loneliness the other theme aside from friendship?

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John Steinbeck's novella, Of Mice and Men, has many different themes highlighted within the text. That said, one theme (set in contrast with another) is the idea of friendship and loneliness. While it may seem that each are far too contrasting to be aligned, the ideas presented with each tie together through the contrast. 

Essentially, the idea of loneliness is paired with the idea of friendship based upon the relationships depicted within the novella. While the only true friendship seen is the one between Lennie and George , both are essentially lonely. George is lonely because he is contrastingly different from Lennie. While the friendship...

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