We all want relationships in life. George has a best friend in Lennie and that's great, but being handicapped, Lennie doesn't offer much back. George gets nothing from anyone.
In our culture, we have a lifelong relationship we try to turn to: marriage. No, it's not necessary for happiness, but it avoids lonliness for most. (Yes, you can be lonely in a marriage too.) But the point of marriage is lifelong companionship.
George can't even get a date. "If I didn't have you I could get a girl..." he says over and over. George longs for a woman, but no woman is going to understand that he has this crippled attached to him.
In Of Mice and Men, George is a lonely character for many reasons. First, he is constantly traveling and has no family. He works and tries to save because he would like to be his own boss one day. This is a problem because he has to take care of his mentally handicapped friend, Lennie. Lennie constantly causes problems that cause them to have to move. They are never in one place too long. He does not get time to form relationships or plant "roots" anywhere.
The life of a migrant worker is a very lonely one. The characters Candy, Crooks, and Curley's wife also prove this. Each of them struggles with their lifestyle.
George is lonely because he does not have a life away from Lenny. HIs life is completely dominated by Lennys presence. He does not feel he can have friends and risk them talking to Lenny and hearing something from their past. Further, he cannot have a social life because of LEnny because he must be watched constantly. ALthough Lenny's behavior is completely innocent people don't understand it and so George must protect Lenny from people's vengeance.
In the book "Of Mice and Men" George has to take care of Lenny. He could abandon him, but he carries the responsibility. Having hate care of an individual with a disability has restricted George's life, opportunity to establish relationships, and forced him to move whenever something went wrong.
The life style of a single migrant worker gives way to a lonely life. For example, Candy is a typical aged out ranch hand. He sits by himself often, is left behind when the others go to town, and is alleviated from the income and social environment. If George continues to work as a ranch handle will eventually become like Candy.
The reason why i believe George is a very lonely character is because; George is always around Lennie which make George a character without a life almost, for example when George exploded to Lennie about how he wanted ketchup with his beans and said, ''God almughty, if iw as alone i could live so easy. I could go get a job and work, and no trouble. No mes at all, and when the end of the month come i could take my fifty bucks and go into town and get whatever i want. Why, i could stay in a cat house all night. I could eat any place i want, hotel or any place, and order any damn thing i think.''
George is a lonely character because he has too much responsibility and any one of us know that too much responsibility can interact with our personality and social being. I mean there is a such thing as having responsibility and having too much responsibility.