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From early on, Macduff is suspicious of Macbeth even though Macbeth has not necessarily given anyone any clear reasons to doubt his honor. Macduff thinks that things are suddenly going wrong in Scotland and Macbeth is the prime beneficiary, so he makes it a point to keep an eye on Macbeth's actions. Macduff expresses his contempt for Macbeth when he refuses to attend the coronation ceremony, and from this point, Macbeth just continues to do things that add to Macduff's hatred (killing his family and court). These are some of the reasons why Macduff hates Macbeth.
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