"That death's unnatural that kills for loving," Desdemona says to her husband in Act V, Scene 2 of this play. Desdemona, like the audience, knows that Othello is about to kill her, not because of anything she has done, but because of a misguided belief in her guilt. Desdemona is only one of the victims of Iago's plot to deceive and control his general. By the end of the play, when Othello smothers his wife—"Put out the light, and then put out the light"—almost every person with any attachment or meaning to Iago has been damaged irrevocably by his schemes. His erstwhile friend and conspirator, Roderigo, is dead, slain by Iago's own hand. Meanwhile, Othello has been so thoroughly convinced of his wife's unfaithfulness by of Iago's lies that he kills not only Desdemona but then himself, unable to live with the turmoil in his mind.
There is a scholarly theory that Iago destroys Othello because, paradoxically, he is in love with him. He covets Desdemona's handkerchief, given to her by Othello as a symbol of love, because he perhaps desires to be approved of and loved by his general to the same extent that Desdemona is. If we believe this interpretation, then, Iago loses everything and everyone he loves because of his plotting. He kills his wife, Emilia, because of what she knows; he drives Othello to kill himself and his wife. Whether Iago's true desire is for Othello or Desdemona, he loses both, and he also loses his own freedom.