Which step of glycolysis is reversible in all cells besides liver cells?

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Glycolysis is a metabolic pathway that converts glucose into pyruvate, a three-carbon species. It involves 10 steps, seven of which are reversible while the rest, irreversible. 

The following steps of glycolysis are reversible:

  • Step 2: G6P-F6P Isomerization
  • Step 4: F16BP cleavage (forming G3P and Dihydroxyacetone phosphate)
  • Step 5: Dihydroxyacetone phosphate-G3P Isomerization
  • Step 6: G3P Phosphorylation (forming 1,3-biphosphoglycerate)
  • Step 7: 1,3-biphosphoglycerate Phosphorylation (forming 3PG)
  • Step 8: 3PG-2PG Isomerization
  • Step 9: 2PG Dehydration (forming PEP)

All the other steps are irreversible.



  1. G6P - Glucose-6-phosphate
  2. F6P - Fructose-6-phosphate
  3. F16BP - Fructose-1,6,-biphosphate
  4. Glyceraldehyde-3-phosphate
  5. 3PG - 3-phosphoglycerate
  6. 2PG - 2-phosphoglycerate
  7. PEP - Phosphoenol pyruvate
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