Which step of glycolysis is reversible in all cells besides liver cells?
Glycolysis is a metabolic pathway that converts glucose into pyruvate, a three-carbon species. It involves 10 steps, seven of which are reversible while the rest, irreversible.
The following steps of glycolysis are reversible:
- Step 2: G6P-F6P Isomerization
- Step 4: F16BP cleavage (forming G3P and Dihydroxyacetone phosphate)
- Step 5: Dihydroxyacetone phosphate-G3P Isomerization
- Step 6: G3P Phosphorylation (forming 1,3-biphosphoglycerate)
- Step 7: 1,3-biphosphoglycerate Phosphorylation (forming 3PG)
- Step 8: 3PG-2PG Isomerization
- Step 9: 2PG Dehydration (forming PEP)
All the other steps are irreversible.
- G6P - Glucose-6-phosphate
- F6P - Fructose-6-phosphate
- F16BP - Fructose-1,6,-biphosphate
- 3PG - 3-phosphoglycerate
- 2PG - 2-phosphoglycerate
- PEP - Phosphoenol pyruvate