The most significant of these rights is the right to freedom of speech. This right has been called the "guardian of every other right." For this reason, it is the most significant.
If we lose other of our rights, we can use our freedom of speech to protest the loss. This can allow us to regain those other rights through political action. For example, a gun rights activist might say that they have lost their Second Amendment rights. However, through free speech (and the fact that that freedom allows interest groups like the NRA to operate), they are gradually winning back this freedom.
As long as we have the freedom of speech, we can argue for our other rights. If our freedom of speech were taken away, how would we persuade the government to give it back?