What's the advantages of the conditional knockout?

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gsenviro | College Teacher | (Level 1) Educator Emeritus

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Conditional knockout is a genetic engineering technique that allows targeted removal of specific gene from a particular organ. This is in contrast to traditional gene knockout technique where the gene is knocked out from the entire body.

The various advantages of conditional knockout technique are:

  • traditional gene knockout technique based mice exhibit embryonic and early postnatal fatality. This deficiency can be overcome by using conditional knockout method.
  • the gene function in a particular tissue or cell type can be examined at any given time point
  • chromosomal abnormalities that cause human diseases can be studied using mice prepared by conditional knockout method.
  • It has also been suggested that mice prepared with conditional knockout technique have longer life span, as compared to lines prepared by conventional technique.
  • commercially prepared mouse lines save time and effort in the lab.

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