Well, you have a number of possibilities, but to be honest, the approach that I would probably take would be to think about what this quote says about the character of Puck and use it to analyse his role in the play, particularly given his penchant for causing mischief and problems. Let us remember what Puck gleefully shares with the fairy in this section:
I am that merry wanderer of the night.
I jest to Oberon and make him smile
When I a fat and bean-fed horse beguile,
Neighing in likeness of a filly foal:
And sometime lurk I in a gossip's bowl,
In very likeness of a roasted crab,
And when she drinks, against her lips I bob
And on her wither'd dewlap pour the ale.
Puck is deliberately presented as the kind of character that lives for tricking people and making them laugh, playing pranks at every turn. This should make us become incredibly suspicious of his supposed ignorance when he mistakes the identity of the Athenian lovers and causes chaos when they all start falling in love with the wrong people. Therefore, a very interesting thesis statement that you might like to think about would be something like:
The character of Puck in A Midsummer Night's Dream is shown to be a force for chaos in the play.
Such a thesis statement would allow you to analyse the character of Puck as he is presented in this quote and elsewhere, and crucially, whether you think he deliberately causes the problems with the Athenian lovers.