This a great question. There were so many hardships that I will have to be selective. I will address the economic hardships and then some psychological hardships.
As you know the Great Depression caused many banks to fail and this sent large ripples into society. For instance, the stock markets crashed and people lost their saving. This also caused many companies to close up, because there was little borrowing in view of the bank failures. This cause many people to lose their jobs all throughout society. The unemployment rate went through the roof.
When this happened, more factories closed, because no one had money to spend. Who would buy good? Entertainment and all other non-essential spending went down as well. This caused great economic hardship for many American families to the point where many families subsisted on handouts from the government.
There were also emotional and psychological problems. Many father and some mother took to the road in search for job. This broke up families, which caused great strains. Many students in college also could not afford the tuition. And even if they could afford it, they dropped out of school to help their families.