The time of the Renaissance is called by such a name, because there was really a rebirth of Europe. There are too many creations to name. So, I will be selective.
From an architectural point of view, the greatest building of the Renaissance is probably St. Peter basilica (by Giacomo della Porta). It is still there in Vatican city, and it was started in 1546. Seeing it is breathtaking. Other great buildings include the Teatro Olimpico by Andrea Pallidio in Vicenza and the Tempietto of San Pietra by Donato Bramate in Rome. There are literally hundreds of amazing buildings. From this perspective, architecture took a huge jump, which has a lasting impression today.
From the point of view of art, we have an embarrassment of riches. Here is a list of some artists and their works: Donatello's David, Michaelangelos' work on the Sistine Chapel ceiling, Sandro Botticelli's Magnificat, and so much more. Going to any of the great museum will show you the brilliance of the art.
Also it should be noted that the Renaissance also produced great artist from all over Europe. For example, French artists include: Jean Fouquet, Nicholas Froment, and Simon Marmion. Spanish artists include: Pedro Berruguete, Ayne Bru, and Jaume Huget. Dutch and Flemish artists include: Dirk Bouts, Jan Van Eyck, and Hans Memling.