I don't think either of these is completely true. Victor was in turmoil about his role in Justine's predicament...he is feeling remorse and guilt, and also regretting putting Elizabeth and the rest of his loved ones in this situation...yet, he remains silent about his creation. After Clerval's murder trial, I think it is much the same. He is relieved to be leaving the prison, relieved to see his father's loving face, and more guilt and regret for losing Henry when it wasn't necessary. Victor had the power to stop and prevent it all, yet he is weak and self-centered. We do see him change a little later in the book, but the change comes too late to save his loved ones.
Victor Frankenstein is the gothic villain-hero whose soul is in chaos; he becomes irrational and somewhat twisted in his thinking as he once leaves his loving world of family after each trial. He feels compelled to destroy the creature, but his pride will not allow him to confess his act against Nature.
After the trials of his loved ones, he does feel some guilt, but he always considers his own self-preservation first; that is, until he become desperate in his drive to destroy the creature.