What was the effect of discovery of the Americas by Europeans on Native Americans?

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As stated above, Europeans brought with them many diseases to which Native Americans had no immunity, with devastating effects on Native communities. According to Charles C. Mann in the 2005 book 1491, the Native American population in North and South America was much larger than has been previously estimated, and diseases wiped out much more of the population than perviously thought.

Cultural misunderstandings about land ownership and what that meant caused conflicts between Native groups and European settlers. Already reduced Native populations were often forced off their land, disrupting cultures and religions that were tied closely to a particular geography.

As the European culture of the United States...

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