The full quote is, "O brave new world that has such people in it. Let's start at once" (166). The second sentence gives the first more meaning. John says this after he has met Bernard and Lenina and is invited to go back to their society with them. At this point in the book, before chapter nine, John has endured the retelling of his life on the reservation as an outcast. He has hope that by living in a different society, he will find acceptance and peace that he had not found previously in his life of loneliness. It is also an ironic statement because he expects (well, more hopes) to find a new and happy life, but he is dealt exactly the opposite. He later is disappointed in the people in the new world because they are controlled by substances and brainwashing rather than living in the manner of happiness that he had desired and learned about after reading the Bible and the works of Shakespeare.