One possible thesis is the arrogance of man, how in his desire to control nature, he often ends up causing pain and suffering. Science is an instrument of that control and can be used for both good and ill. Griffin, in his arrogance, has deliberately chosen to use his scientific knowledge and skill to wreak a terrible revenge on a world he's come to hate. As with Frankenstein, The Invisible Man shows us what can happen when we abuse science, when we see it as an instrument of control over others, instead of harnessing its wondrous power to make life better for everyone. Wells is suggesting that we must approach scientific research with the right attitude, with an appropriate attitude of humility and respect for our fellow human beings. As Griffin has neither of these qualities, science becomes a dangerous weapon in his hands.