I think that one of the most pressing themes that comes out of the film is the basic notion of free will vs. determinism. The question becomes how lives change if the smallest of details are altered. Essentially, is consciousness constructed in an entire sequence that is already predetermined? Is consciousness based on causality? Do human beings have the power to alter an outcome that is either not known or predetermined and unknown to us? All of these themes come into play in the different runs in the film. The smallest of changes alter the sequence of events in a dramatic, and in some senses, traumatic manner. It is here where the theme of freedom vs. free will is evident. As human consciousness is unable to see past what is incapable of understanding, these questions occupy greater importance. The different endings to Lola's runs are even more intriguing when assessing the slight changes made in each. It is here where the theme of how human consciousness understands freedom vs. predetermined configuration becomes apparent and represents one of the strongest themes in the film.