I think that one particular topic that can be explored is who bears the ultimate responsibility for Macbeth's predicament. This would be the initial question posed. The theme that this explores is the nature of evil that is evoked in the drama. This is arguable for a couple of reasons in terms of ascertaining the nature of Macbeth's ambition. On one hand, it can be argued that Macbeth is responsible for his own demise. His predicament can be assessed as being the result of his own actions. Another point of analysis could be that he was motivated by Lady Macbeth, his wife. In terms of analysis, I think that a case can be made that she was the initiating agent of Macbeth's actions. Another area that can be examined would be the role of the witches in Macbeth's predicament. The role of the witches and the notion of the supernatural as well as Macbeth's belief in it could be assessed as part of this configuration, as well. In this, I think that there can be some significant points of discussion as to who is ultimately responsible for what happens to Macbeth in the drama.