The Last Lecture was not delivered as a commentary about Randy Pausch's family, although he reveals at the end that the content of the presentation was dedicated to and for his children. However, the speech reflected his love of and concern for his wife and children and their welfare after his death.
He explained that they moved - "we just decamped" - to Virginia so they would be living closer to Jai's family. He relates the importance of "winning stuffed animals" to impress his wife, and supports the story with a display of his winnings brought onto the stage. Randy makes the point that it is important to "focus on other people, not on yourself" and demonstrates by having a birthday cake for his wife wheeled onto the stage and leads the audience in singing "Happy Birthday" to her.