Lennie and Curley's wife both find themselves separated from the rest of the group for different reasons. With Lennie, he's just not able to socially keep up and compete with the other guys. With Curley's wife, she just doesn't have any girlfriends. Because of this separation, they both feel vunerable, lonely, and abandoned. This separation can be shown through their discussion in chapter 5:
"Why can't I talk to you? I never get to talk to nobody. I get awful lonely."
Lennie said, "Well, I ain't supposed to talk to you or nothing.
Further on, we see that they both have incredible dreams that they stake their life hope in. Curley's wife says:
Could been in the movies, an' had nice clothes - all them nice clothes they wear. An' I coulda sat in them big hotels, an' had pitcher took of me.
Lennie's dream is different, but serves the same purpose:
We gonna have a little place... We gonna have a house an' a garden and a place for alfalfa, an' that alfalfa is for the rabbits, an' T take a sack and get it all fulla alfalfa and then I take it to the rabbits.
Obviously, they both have hope, although for each the hope is truly an unrealistic one.
Hope that helps.
they're both lonely and seperated from other guys