Great question, as both of these stories have very strong similarities but also some big differences too. Clearly the similarities are that both stories contain two enemies that are engaged in a mortal struggle against each other. Both of these struggles take place in a natural environment as both enemies seek to kill their opponent, and thus both stories represent a desperate struggle to survive and to outlive the other.
However, it is clear that there are also significant differences. In "The Interlopers," for example, the two enemies become friends because of the desperate situation they find themselves in and heal the breach between their two households, which does not occur in "The Most Dangerous Game." Likewise, "The Interlopers" ends with a piece of tragic, dark irony as instead of being rescued from the tree they are trapped by, a pack of wolves comes and kills them. Tragically, instead of both surviving to live in peace, or even one surviving having killed the other, as in "The Most Dangerous Game," both die terribly together.