In the story "Flowers for Algernon," the main character, Charlie Gordon, is a mentally disabled man who undergoes an experimental procedure to triple his intelligence. Scientists have previously tested the surgery only on lab mice. The mouse who has "stayed smart" the longest is named Algernon.
Although Charlie at first resents Algernon for beating him at maze tests, over time Charlie develops a bond with the lab mouse. As the story progresses, first Algernon and then Charlie gain intelligence rapidly, then begin to deteriorate. Ultimately, Algernon dies and Charlie ends up back where he started--with an IQ of 68 and a job as a janitor in a factory. Naturally, Charlie forgets most of what he learned with his artificially enhanced intelligence, but he remembers Algernon fondly as a fellow "guinea pig" and asks that the mouse be honored by placing flowers on his grave.