In Frankenstien, in what sense does the romance contain an apology to the family; how is the deprived life a comfort?
Shelley makes Victor Frankenstein a tragic hero, meaning a hero that is brought down by his own failing. His tragic flaw is alienation. Instead of embracing his family, and allowing them to embrace him in his troubles, he alienates everyone - his father, his friend, Elizabeth, and his creation. He continues to try to run away, and by doing so, he forges the path to his failure. Had he accepted parental responsibility for his creation, the creation would not have sought vengenance. William, Justin, Clerval, Elizabeth -- all of these characters might have been spared their fate. However, Victor abadons his family at every turn, and suffers for it. Shelley idealizes family in the same way she does nature.
The deprived life could be interpreted as the ignorant life. The more knowledge that a person gains, the more complexity he/she also gains. The more wealth, the more responsibility. Victor is blessed with intelligence and education and wealth - and look what happens to him. Walton is blessed with knowledge and enough wealth to explore, and Shelley leads us to believe that it almost kills him as well. The more knowledge the creature gains, from watching the De Lacy's, the more his fire for revenge gets stoked. So, your theme - "the deprived life is a comfort" - could easily be related to the old adage - "ignorance is bliss".