What is the role of fibrin in blood clotting?

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ako6777 | Middle School Teacher | (Level 1) Associate Educator

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Fibrin is an insoluble protien found in blood.  It is fibrous and aides in clotting by forming a fibrous mesh. This mesh entangles platelets over a wound site causing a plug to form.  Fibrin is manufactured by the liver. 

Too much fibrin can lead to a blood clot while too little fibrin can lead to hemorraging.  Having too little fibrin can also lead to hemophilia in people.  Deficiencies and excess production of fibrin can be determined by examining blood plasma in the lab.  Normal levels of fibrin in the blood are about 1.5-2.77 g/L.

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giorgiana1976 | College Teacher | (Level 3) Valedictorian

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Fibrin is a protein substance that is synthesized by the liver and plays an essential role in blood clotting.

Fibrin is formed through polymerization and is the component of the clot, that stops the bleeding.

The doctor may recommend the fibrin test if the patient shows deficiencies in coagulation or if suffering from massive bleeding.

The normal values of fibrin in the blood: 200-400 mg per 100 ml of blood.

Decrease of fibrin levels mentioned above can cause bleeding in patients who have liver disease.

Fibrin increases, over values mentioned above, appear in acute infectious diseases and especially in rheumatic fever.

Relatively high levels of fibrin are occurring during pregnancy.

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