As president, the main issues that Andrew Jackson faced were issues that were based on class. Jackson saw himself as the "tribune" of the common people, the person who was to watch out for their interests. This perception of himself had a great deal to do with the issues he thought were important.
The biggest issue of Jackson's presidency was the "Bank War." In this incident, Pres. Jackson chose to try to destroy the Second Bank of the United States. He felt that it was an institution run by and for the elites of the country at the expense of the common people.
The Bank War was the defining incident of Jackson's presidency. It was typical of the major issues he faced which were (in his opinion) issues of how to protect the common people from the elites.