What is the probability of the offspring that is a daughter having hemophilia if a man with hemophilia were to marry a woman who is not a carrier of hemophilia.

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justaguide | College Teacher | (Level 2) Distinguished Educator

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Hemophilia is a disorder in the way the clotting factor VIII or IX is made by the body. The genes that control this process are found in the X-chromosome.

Males have one X-chromosome and one Y-chromosome while females have 2 X-chromosomes.

If a man who has hemophilia were to have a female offspring with a woman who does not have hemophilia, the probability of the girl child having hemophilia is zero.

As the offspring receives the X-chromosome from her father which has the hemophilia gene and another X-chromosome from the mother that is normal, the daughter will be a carrier of hemophilia.

Carriers of hemophilia can make enough of the clotting factor to avoid serious bleeding that is associated with hemophilia, though around 50% of carriers have a slightly increased risk of bleeding.

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