Certainly, the ambition of Claudius to be king in "Hamlet" is pivotal to the tragedies that follow in the play. In fact, Claudius himself falls victim to tragic consequences. In Act IV he exclaims, "My soul is full of discord and dismay"(IV,i,45).
Because of his father's murder, Hamlet sinks into deep melancholia; he feels antipathy toward his mother and Ophelia, whom he really loves. In fact, Hamlet develops a mistrust of nearly everyone. In speaking of his mother, for example, he remarks, "That one can smile and smile and be a villain"(I,v,23).
A classic, "The Count of Monte Cristo," by Alexandre Dumas has a plot set around the evil ambition of three men who have falsely sent to prison an innocent young man. Having escaped, the innocent man returns to the world to act as nemesis for these exigent men and their careers are destroyed as their pasts and all their evil deeds exposed by Edmund Dantes.
Charles Dicken's novel, "Great Expectations" demonstrates the falseness of Pip's ambitions to become a gentleman. In his ambition to attain social status and be a respectable gentleman of property, Pip makes many mistakes and hurts those who really love him. His false values do not serve him, and he must return to the genuine love of family and friends.
A short work that parables the negative effects of monetary ambition is "The Pearl" by J. Steinbeck as greed destroys a family.