What is one negative result of the Columbian Exchange?  

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One of the biggest negative results of the Colombian exchange was the destruction and demise of many aspects of the indigenous cultures found in the Americas. Intent on claiming resources and materials that they found for their country, the "conquistadores," or conquering people, trampled and destroyed many aspects of indigenous culture, such as artwork, tribal languages, and religions, in the name of conquest. As the conquering people settled into their new territories, they brought with them their languages and values and imposed them upon the native people of the Americas. Because of this, many of the tribal languages fell out of use and became extinct. Today, only a fraction of native languages still remain. As well as languages, indigenous religions were absorbed into the presiding religions that were brought over. Both Catholic and Protestant religions acquired many new converts, who were forcibly converted under threat of death. The elimination of many tribal languages and religions weakened and destroyed important aspects of the native cultures and therefore was one of the most long-lasting and negative results of the Colombian exchange.

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The biggest negative effect of the Columbian Exchange was the introduction of European diseases to the Americas. Diseases like typhus, measles, plague, and especially smallpox devastated Native Americans who had no immunity to them. The death toll, which some historians estimate at close to 90% of the indigenous population before contact, makes this aspect of the Columbian Exchange one of the worst demographic disasters in the history of the world. Native peoples who were lucky enough to be spared by these diseases, which hit in waves of so-called "virgin soil epidemics," saw their lives change dramatically. Villages and entire tribes of people were forced to seek shelter with other native groups, and many were adopted into tribes like the Catawba, which emerged in the seventeenth and eighteenth centuries in response to the disaster. Disease also facilitated the conquest of many Native peoples, perhaps most famously the Inca, who faced a terrible smallpox epidemic that paved the way for Pizarro and his conquistadores. So the spread of epidemic diseases was by far the worst impact of the Columbian Exchange.

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